
Offen’s Lab of Translational Neuroscience
Felsenstein Medical Research Center
Dept. of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine
Sagol School of Neuroscience
Tel Aviv University

PUBLICATIONS
2019
Angel A, Volkman R, Royal TG, Offen D.
Int J Mol Sci. 2020 Feb 9;21(3). pii: E1144. doi: 10.3390/ijms21031144.
Volkman R, Ben-Zur T, Kahana A, Garty BZ, Offen D.
Front Neurosci. 2019 Sep 24;13:990. doi: 10.3389/fnins.2019.00990. eCollection 2019.
Guo S, Perets N, Betzer O, Ben-Shaul S, Sheinin A, Michaelevski I, Popovtzer R, Offen D, Levenberg S.
ACS Nano. 2019 Sep 24;13(9):10015-10028. doi: 10.1021/acsnano.9b01892. Epub 2019 Aug 29.
Guy R, Grynspan F, Ben-Zur T, Panski A, Lamdan R, Danon U, Yaffe D, Offen D.
Front Neurosci. 2019 Feb 27;13:151. doi: 10.3389/fnins.2019.00151. eCollection 2019.
The Role of MAPK's Signaling in Mediating ApoE4-Driven Pathology In Vivo.
Salomon-Zimri S, Koren A, Angel A, Ben-Zur T, Offen D, Michaelson DM.
Curr Alzheimer Res. 2019;16(4):281-292. doi: 10.2174/1567205016666190228120254.
Perets N, Betzer O, Shapira R, Brenstein S, Angel A, Sadan T, Ashery U, Popovtzer R, Offen D.
Nano Lett. 2019 Jun 12;19(6):3422-3431. doi: 10.1021/acs.nanolett.8b04148. Epub 2019 Feb 27.
2018
Perets N, Hertz S, London M, Offen D.
Mol Autism. 2018 Nov 21;9:57. doi: 10.1186/s13229-018-0240-6. eCollection 2018.
Cannabidiol as a suggested candidate for treatment of autism spectrum disorder.
Poleg S, Golubchik P, Offen D, Weizman A.
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Aug 29. doi: 10.1016/j.pnpbp.2018.08.030.
Combined Gene Therapy to Reduce the Neuronal Damage in the Mouse Model of Focal Ischemic Injury.
Molcho L, Ben-Zur T, Barhum Y, Angel A, Glat M, Offen D.
J Mol Neurosci. 2018 Sep 3. doi: 10.1007/s12031-018-1143-x.
DJ-1 based peptide, ND-13, promote functional recovery in mouse model of focal ischemic injury
Molcho L, Ben-Zur T, Barhum Y, Offen D.
PLoS One. 2018 Feb 28. doi: 10.1371/journal.pone.0192954.
2017
Ganz J, Shor E, Guo S, Sheinin A, Arie I, Michaelevski I, Pitaru S, Offen D, Levenberg S.
Front. Neurosci. 2017 October 31. doi: 10.3389/fnins.2017.00589.
In Vivo Neuroimaging of Exosomes Using Gold Nanoparticles.
Betzer O, Perets N, Angel A, Motiei M, Sadan T, Yadid G, Offen D, Popovtzer R.
ACS Nano. 2017 Sep 29. doi: 10.1021/acsnano.7b04495.
Toll-Like Receptor-4 Inhibitor TAK-242 Attenuates Motor Dysfunction and Spinal Cord Pathology in an Amyotrophic Lateral Sclerosis Mouse Model.
Fellner A, Barhum Y, Angel A, Perets N, Steiner I, Offen D, Lev N.
Int J Mol Sci. 2017 Aug 1;18(8). pii: E1666. doi: 10.3390/ijms18081666.
Segal-Gavish H, Barzilay R, Rimoni O, Offen D.
World J Biol Psychiatry. 2017 Jun 8:1-10. doi: 10.1080/15622975.2017.1323118.
Concise Review: Mesenchymal Stem Cells in Neurodegenerative Diseases.
Volkman R, Offen D.
Stem Cells. 2017 Jun 7. doi: 10.1002/stem.2651.Review.
Segal-Gavish H, Danino O, Barhum Y, Ben-Zur T, Shai E, Varon D, Offen D, Fischer B.
J Alzheimers Dis. 2017;58(2):389-400. doi: 10.3233/JAD-161236.
Segal-Gavish H, Gazit N, Barhum Y, Ben-Zur T, Taler M, Henry Hornfeld S, Gil-Ad I, Weizman A, Slutsky I, Niwa M, Kamiya A, Sawa A, Offen D, Barzilay R.
Hum Mol Genet. 2017 Apr 11. doi: 10.1093/hmg/ddx139.
Perets N, Segal-Gavish H, Gothelf Y, Barzilay R, Barhum Y, Abramov N, Hertz S, Morozov D, London M, Offen D.
Behav Brain Res. 2017 Jul 28;331:254-260. doi: 10.1016/j.bbr.2017.03.047.
Gross A, Benninger F, Madar R, Illouz T, Griffioen K, Steiner I, Offen D, Okun E.
Epilepsia. 2017 Apr;58(4):586-596. doi: 10.1111/epi.13688.
2016
Barzilay R, Ventorp F, Segal-Gavish H, Aharony I, Bieber A, Dar S, Vescan M, Globus R, Weizman A, Naor D, Lipton J, Janelidze S, Brundin L, Offen D.
J Mol Neurosci. 2016 Dec;60(4):548-558.
Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment.
Salomon-Zimri S, Glat MJ, Barhum Y, Luz I, Boehm-Cagan A, Liraz O, Ben-Zur T, Offen D, Michaelson DM.
J Alzheimers Dis. 2016 Jun 30;53(4):1443-58. doi: 10.3233/JAD-160182.
Glat MJ, Ben-Zur T, Barhum Y, Offen D.
PLoS One. 2016 Feb 22;11(2):e0148170. doi: 10.1371/journal.pone.0148170.
Ventorp F, Barzilay R, Erhardt S, Samuelsson M, Träskman-Bendz L, Janelidze S, Weizman A, Offen D, Brundin L.
J Affect Disord. 2016 Mar 15;193:349-54. doi: 10.1016/j.jad.2015.12.069.
Petrou P, Gothelf Y, Argov Z, Gotkine M, Levy YS, Kassis I, Vaknin-Dembinsky A, Ben-Hur T, Offen D, Abramsky O, Melamed E, Karussis D.
JAMA Neurol. 2016 Mar;73(3):337-44. doi: 10.1001/jamaneurol.2015.4321.
Benkler C, Barhum Y, Ben-Zur T, Offen D.
J Mol Neurosci. 2016 Jan;58(1):46-58. doi: 10.1007/s12031-015-0695-2.
Benninger F, Glat MJ, Offen D, Steiner I.
J Clin Neurosci. 2016 Apr;26:75-8. doi: 10.1016/j.jocn.2015.10.008.
Ectopic Muscle Expression of Neurotrophic Factors Improves Recovery After Nerve Injury.
Glat MJ, Benninger F, Barhum Y, Ben-Zur T, Kogan E, Steiner I, Yaffe D, Offen D.
J Mol Neurosci. 2016 Jan;58(1):39-45. doi: 10.1007/s12031-015-0648-9.
Segal-Gavish H, Karvat G, Barak N, Barzilay R, Ganz J, Edry L, Aharony I, Offen D, Kimchi T.
Autism Res. 2016 Jan;9(1):17-32. doi: 10.1002/aur.1530.
2015
Lev N, Barhum Y, Ben-Zur T, Aharony I, Trifonov L, Regev N, Melamed E, Gruzman A, Offen D.
PLoS One. 2015 May 29;10(5):e0127549. doi: 10.1371/journal.pone.0127549.
DJ-1 knockout augments disease severity and shortens survival in a mouse model of ALS.
Lev N, Barhum Y, Lotan I, Steiner I, Offen D.
PLoS One. 2015 Mar 30;10(3):e0117190. doi: 10.1371/journal.pone.0117190.
Getter T, Zaks I, Barhum Y, Ben-Zur T, Böselt S, Gregoire S, Viskind O, Shani T, Gottlieb H, Green O, Shubely M, Senderowitz H, Israelson A, Kwon I, Petri S, Offen D, Gruzman A.
ChemMedChem. 2015 May;10(5):850-61. doi: 10.1002/cmdc.201500045.
Aharony I, Ehrnhoefer DE, Shruster A, Qiu X, Franciosi S, Hayden MR, Offen D.
Hum Mol Genet. 2015 May 1;24(9):2604-14. doi: 10.1093/hmg/ddv023.
Dadon-Nachum M, Ben-Yaacov K, Ben-Zur T, Barhum Y, Yaffe D, Perlson E, Offen D.
J Mol Neurosci. 2015 Mar;55(3):788-97. doi: 10.1007/s12031-014-0426-0.
PMID:
2014
Gothelf Y, Abramov N, Harel A, Offen D.
Clin Transl Med. 2014 Jul 10;3:21. doi: 10.1186/2001-1326-3-21.
Ganz J, Arie I, Buch S, Zur TB, Barhum Y, Pour S, Araidy S, Pitaru S, Offen D.
PLoS One. 2014 Jun 19;9(6):e100445. doi: 10.1371/journal.pone.0100445.
Alginate-coated magnetic nanoparticles for noninvasive MRI of extracellular calcium.
Bar-Shir A, Avram L, Yariv-Shoushan S, Anaby D, Cohen S, Segev-Amzaleg N, Frenkel D, Sadan O, Offen D, Cohen Y.
NMR Biomed. 2014 Jul;27(7):774-83. doi: 10.1002/nbm.3117.
Harnessing neurogenesis for the possible treatment of Parkinson's disease.
Lamm O, Ganz J, Melamed E, Offen D.
J Comp Neurol. 2014 Aug 15;522(12):2817-30. doi: 10.1002/cne.23607. Epub 2014 May 9. Review.
Ganz J, Arie I, Ben-Zur T, Dadon-Nachum M, Pour S, Araidy S, Pitaru S, Offen D.
Stem Cells Transl Med. 2014 Mar;3(3):375-86. doi: 10.5966/sctm.2013-0074.
Targeting neurogenesis ameliorates danger assessment in a mouse model of Alzheimer's disease.
Shruster A, Offen D.
Behav Brain Res. 2014 Mar 15;261:193-201. doi: 10.1016/j.bbr.2013.12.028. Epub 2013 Dec 31.
Rare combination of myasthenia and motor neuronopathy, responsive to Msc-Ntf stem cell therapy.
Petrou P, Argov A, Lennon VA, Gotkine M, Kassis I, Vaknin-Dembinsky A, Ben-Hur T, Offen D, Abramsky O, Melamed E, Karussis D.
Muscle Nerve. 2014 Mar;49(3):455-7. doi: 10.1002/mus.24143.
Kaminitz A, Barzilay R, Segal H, Taler M, Offen D, Gil-Ad I, Mechoulam R, Weizman A.
World J Biol Psychiatry. 2014 Jan;15(1):76-82. doi: 10.3109/15622975.2013.841993.
2013
Kandinov B, Grigoriadis NC, Touloumi O, Drory VE, Offen D, Korczyn AD.
Amyotroph Lateral Scler Frontotemporal Degener. 2013 Sep;14(5-6):424-33. doi: 10.3109/21678421.2013.780622.
Knocking out DJ-1 attenuates astrocytes neuroprotection against 6-hydroxydopamine toxicity.
Lev N, Barhum Y, Ben-Zur T, Melamed E, Steiner I, Offen D.
J Mol Neurosci. 2013 Jul;50(3):542-50. doi: 10.1007/s12031-013-9984-9. Epub 2013 Mar 28.
Cell and gene therapy in Alzheimer's disease.
Glat MJ, Offen D.
Stem Cells Dev. 2013 May 15;22(10):1490-6. doi: 10.1089/scd.2012.0633. Epub 2013 Mar 4. Review.
Benkler C, Ben-Zur T, Barhum Y, Offen D.
Glia. 2013 Mar;61(3):312-26. doi: 10.1002/glia.22428.
Barzilay R, Ganz J, Sadan O, Ben-Zur T, Bren Z, Hinden N, Taler M, Lev N, Gil-Ad I, Weizman A, Offen D.
Eur Neuropsychopharmacol. 2013 Sep;23(9):1115-23. doi: 10.1016/j.euroneuro.2012.10.002.
2012
Sadan O, Melamed E, Offen D.
PLoS Curr. 2012 Jul 10;4:e4f7f6dc013d4e. doi: 10.1371/4f7f6dc013d4e.
DJ-1 protects against dopamine toxicity: implications for Parkinson's disease and aging.
Lev N, Barhum Y, Pilosof NS, Ickowicz D, Cohen HY, Melamed E, Offen D.
J Gerontol A Biol Sci Med Sci. 2013 Mar;68(3):215-25. doi: 10.1093/gerona/gls147.
Wnt signaling enhances neurogenesis and improves neurological function after focal ischemic injury.
Shruster A, Ben-Zur T, Melamed E, Offen D.
PLoS One. 2012;7(7):e40843. doi: 10.1371/journal.pone.0040843.
Transplantation of placenta-derived mesenchymal stem cells in the EAE mouse model of MS.
Fisher-Shoval Y, Barhum Y, Sadan O, Yust-Katz S, Ben-Zur T, Lev N, Benkler C, Hod M, Melamed E, Offen D.
J Mol Neurosci. 2012 Sep;48(1):176-84. doi: 10.1007/s12031-012-9805-6.
Sadan O, Shemesh N, Barzilay R, Dadon-Nahum M, Blumenfeld-Katzir T, Assaf Y, Yeshurun M, Djaldetti R, Cohen Y, Melamed E, Offen D.
Exp Neurol. 2012 Apr;234(2):417-27. doi: 10.1016/j.expneurol.2011.12.045.
Dadon-Nachum M, Ben-Zur T, Srugo I, Shamir HM, Melamed E, Yaffe D, Offen D.
J Stem Cells Regen Med. 2012 Apr 14;8(1):21-7.
Shemesh N, Barazany D, Sadan O, Bar L, Zur Y, Barhum Y, Sochen N, Offen D, Assaf Y, Cohen Y.
Magn Reson Med. 2012 Sep;68(3):794-806. doi: 10.1002/mrm.23300.
Yust-Katz S, Fisher-Shoval Y, Barhum Y, Ben-Zur T, Barzilay R, Lev N, Hod M, Melamed E, Offen D.
Cytotherapy. 2012 Jan;14(1):45-55. doi: 10.3109/14653249.2011.613928.
2011
Stem cells treatment for sciatic nerve injury.
Dadon-Nachum M, Melamed E, Offen D.
Expert Opin Biol Ther. 2011 Dec;11(12):1591-7. doi: 10.1517/14712598.2011.628933. Review.
Cell replacement therapy for Parkinson's disease: how close are we to the clinic?
Ganz J, Lev N, Melamed E, Offen D.
Expert Rev Neurother. 2011 Sep;11(9):1325-39. doi: 10.1586/ern.11.74. Review.
PMID:
Ben-Pazi H, Sadan O, Offen D.
J Mol Neurosci. 2012 Jan;46(1):162-6. doi: 10.1007/s12031-011-9559-6.
Differentiated mesenchymal stem cells for sciatic nerve injury.
Dadon-Nachum M, Sadan O, Srugo I, Melamed E, Offen D.
Stem Cell Rev. 2011 Sep;7(3):664-71. doi: 10.1007/s12015-010-9227-1.
Barzilay R, Ben-Zur T, Sadan O, Bren Z, Taler M, Lev N, Tarasenko I, Uzan R, Gil-Ad I, Melamed E, Weizman A, Offen D.
Transl Psychiatry. 2011 Dec 13;1:e61. doi: 10.1038/tp.2011.64.
Shruster A, Eldar-Finkelman H, Melamed E, Offen D.
J Neurochem. 2011 Feb;116(4):522-9. doi: 10.1111/j.1471-4159.2010.07131.
The "dying-back" phenomenon of motor neurons in ALS.
Dadon-Nachum M, Melamed E, Offen D.
J Mol Neurosci. 2011 Mar;43(3):470-7. doi: 10.1007/s12031-010-9467-1. Review.
Levkovitch-Verbin H, Sadan O, Vander S, Rosner M, Barhum Y, Melamed E, Offen D, Melamed S.
Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6394-400. doi: 10.1167/iovs.09-4310.
Mesenchymal stem cells stimulate endogenous neurogenesis in the subventricular zone of adult mice.
Kan I, Barhum Y, Melamed E, Offen D.
Stem Cell Rev. 2011 Jun;7(2):404-12. doi: 10.1007/s12015-010-9190-x.