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Caspase-6 Knockout in the 5xFAD Model of Alzheimer's Disease Reveals Favorable Outcome on Memory and Neurological Hallmarks.

Angel A, Volkman R, Royal TG, Offen D.

Int J Mol Sci. 2020 Feb 9;21(3). pii: E1144. doi: 10.3390/ijms21031144.

Myeloperoxidase Deficiency Inhibits Cognitive Decline in the 5XFAD Mouse Model of Alzheimer's Disease.

Volkman R, Ben-Zur T, Kahana A, Garty BZ, Offen D.

Front Neurosci. 2019 Sep 24;13:990. doi: 10.3389/fnins.2019.00990. eCollection 2019.


Intranasal Delivery of Mesenchymal Stem Cell Derived Exosomes Loaded with Phosphatase and Tensin Homolog siRNA Repairs Complete Spinal Cord Injury.

Guo S, Perets N, Betzer O, Ben-Shaul S, Sheinin A, Michaelevski I, Popovtzer R, Offen D, Levenberg S.

ACS Nano. 2019 Sep 24;13(9):10015-10028. doi: 10.1021/acsnano.9b01892. Epub 2019 Aug 29.

Human Muscle Progenitor Cells Overexpressing Neurotrophic Factors Improve Neuronal Regeneration in a Sciatic Nerve Injury Mouse Model.

Guy R, Grynspan F, Ben-Zur T, Panski A, Lamdan R, Danon U, Yaffe D, Offen D.

Front Neurosci. 2019 Feb 27;13:151. doi: 10.3389/fnins.2019.00151. eCollection 2019.

The Role of MAPK's Signaling in Mediating ApoE4-Driven Pathology In Vivo.

Salomon-Zimri S, Koren A, Angel A, Ben-Zur T, Offen D, Michaelson DM.

Curr Alzheimer Res. 2019;16(4):281-292. doi: 10.2174/1567205016666190228120254.

Golden Exosomes Selectively Target Brain Pathologies in Neurodegenerative and Neurodevelopmental Disorders.

Perets N, Betzer O, Shapira R, Brenstein S, Angel A, Sadan T, Ashery U, Popovtzer R, Offen D.

Nano Lett. 2019 Jun 12;19(6):3422-3431. doi: 10.1021/acs.nanolett.8b04148. Epub 2019 Feb 27.


Intranasal administration of exosomes derived from mesenchymal stem cells ameliorates autistic-like behaviors of BTBR mice.

Perets N, Hertz S, London M, Offen D.

Mol Autism. 2018 Nov 21;9:57. doi: 10.1186/s13229-018-0240-6. eCollection 2018.

Cannabidiol as a suggested candidate for treatment of autism spectrum disorder.

Poleg SGolubchik POffen DWeizman A.

Prog Neuropsychopharmacol Biol Psychiatry. 2018 Aug 29.  doi: 10.1016/j.pnpbp.2018.08.030.

Combined Gene Therapy to Reduce the Neuronal Damage in the Mouse Model of Focal Ischemic Injury.

Molcho LBen-Zur TBarhum YAngel AGlat MOffen D.

J Mol Neurosci. 2018 Sep 3. doi: 10.1007/s12031-018-1143-x.

DJ-1 based peptide, ND-13, promote functional recovery in mouse model of focal ischemic injury

Molcho L,​ Ben-Zur T, Barhum YOffen D.

PLoS One. 2018 Feb 28. doi: 10.1371/journal.pone.0192954. 




Implantation of 3D Constructs Embedded with Oral Mucosa-Derived Cells Induces Functional Recovery in Rats with Complete Spinal Cord Transection.

Ganz J, Shor EGuo S, Sheinin A, Arie IMichaelevski I, Pitaru S, Offen D, Levenberg S.

Front. Neurosci. 2017 October 31. doi: 10.3389/fnins.2017.00589.


In Vivo Neuroimaging of Exosomes Using Gold Nanoparticles.

Betzer O, Perets N, Angel A, Motiei M, Sadan T, Yadid G, Offen D, Popovtzer R.

ACS Nano. 2017 Sep 29. doi: 10.1021/acsnano.7b04495.


Toll-Like Receptor-4 Inhibitor TAK-242 Attenuates Motor Dysfunction and Spinal Cord Pathology in an Amyotrophic Lateral Sclerosis Mouse Model.

Fellner ABarhum YAngel APerets NSteiner IOffen D, Lev N.

Int J Mol Sci. 2017 Aug 1;18(8). pii: E1666. doi: 10.3390/ijms18081666.


Voluntary exercise improves cognitive deficits in female dominant-negative DISC1 transgenic mouse model of neuropsychiatric disorders.

Segal-Gavish H, Barzilay R, Rimoni O, Offen D.

World J Biol Psychiatry. 2017 Jun 8:1-10. doi: 10.1080/15622975.2017.1323118. 

Concise Review: Mesenchymal Stem Cells in Neurodegenerative Diseases.

Volkman R, Offen D.

Stem Cells. 2017 Jun 7. doi: 10.1002/stem.2651.Review.

A Multifunctional Biocompatible Drug Candidate is Highly Effective in Delaying Pathological Signs of Alzheimer's Disease in 5XFAD Mice.

Segal-Gavish H, Danino O, Barhum Y, Ben-Zur T, Shai E, Varon D, Offen D, Fischer B.

J Alzheimers Dis. 2017;58(2):389-400. doi: 10.3233/JAD-161236.

BDNF Overexpression Prevents Cognitive Deficit Elicited by Adolescent Cannabis Exposure and Host Susceptibility Interaction.

Segal-Gavish H, Gazit N, Barhum Y, Ben-Zur T, Taler M, Henry Hornfeld S, Gil-Ad I, Weizman A, Slutsky I, Niwa M, Kamiya A, Sawa A, Offen D, Barzilay R.

Hum Mol Genet. 2017 Apr 11. doi: 10.1093/hmg/ddx139. 

Long term beneficial effect of neurotrophic factors-secreting mesenchymal stem cells transplantation in the BTBR mouse model of autism.

Perets N, Segal-Gavish H, Gothelf Y, Barzilay R, Barhum Y, Abramov N, Hertz S, Morozov D, London M, Offen D.

Behav Brain Res. 2017 Jul 28;331:254-260. doi: 10.1016/j.bbr.2017.03.047.


Toll-like receptor 3 deficiency decreases epileptogenesis in a pilocarpine model of SE-induced epilepsy in mice.

Gross A, Benninger F, Madar R, Illouz T, Griffioen K, Steiner I, Offen D, Okun E.

Epilepsia. 2017 Apr;58(4):586-596. doi: 10.1111/epi.13688. 



CD44 Deficiency Is Associated with Increased Susceptibility to Stress-Induced Anxiety-like Behavior in Mice.

Barzilay R, Ventorp F, Segal-Gavish H, Aharony I, Bieber A, Dar S, Vescan M, Globus R, Weizman A, Naor D, Lipton J, Janelidze S, Brundin L, Offen D.

J Mol Neurosci. 2016 Dec;60(4):548-558.

Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment.

Salomon-Zimri S, Glat MJ, Barhum Y, Luz I, Boehm-Cagan A, Liraz O, Ben-Zur T, Offen D, Michaelson DM.

J Alzheimers Dis. 2016 Jun 30;53(4):1443-58. doi: 10.3233/JAD-160182.

Neuroprotective Effect of a DJ-1 Based Peptide in a Toxin Induced Mouse Model of Multiple System Atrophy.

Glat MJ, Ben-Zur T, Barhum Y, Offen D.

PLoS One. 2016 Feb 22;11(2):e0148170. doi: 10.1371/journal.pone.0148170.

The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood-brain barrier permeability.

Ventorp F, Barzilay R, Erhardt S, Samuelsson M, Träskman-Bendz L, Janelidze S, Weizman A, Offen D, Brundin L.

J Affect Disord. 2016 Mar 15;193:349-54. doi: 10.1016/j.jad.2015.12.069.

Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis: Results of Phase 1/2 and 2a Clinical Trials.

Petrou P, Gothelf Y, Argov Z, Gotkine M, Levy YS, Kassis I, Vaknin-Dembinsky A, Ben-Hur T, Offen D, Abramsky O, Melamed E, Karussis D.

JAMA Neurol. 2016 Mar;73(3):337-44. doi: 10.1001/jamaneurol.2015.4321.

Multifactorial Gene Therapy Enhancing the Glutamate Uptake System and Reducing Oxidative Stress Delays Symptom Onset and Prolongs Survival in the SOD1-G93A ALS Mouse Model.

Benkler C, Barhum Y, Ben-Zur T, Offen D.

J Mol Neurosci. 2016 Jan;58(1):46-58. doi: 10.1007/s12031-015-0695-2. 

Glial fibrillary acidic protein as a marker of astrocytic activation in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis.

Benninger F, Glat MJ, Offen D, Steiner I.

J Clin Neurosci. 2016 Apr;26:75-8. doi: 10.1016/j.jocn.2015.10.008.

Ectopic Muscle Expression of Neurotrophic Factors Improves Recovery After Nerve Injury.

Glat MJ, Benninger F, Barhum Y, Ben-Zur T, Kogan E, Steiner I, Yaffe D, Offen D.

J Mol Neurosci. 2016 Jan;58(1):39-45. doi: 10.1007/s12031-015-0648-9. 

Mesenchymal Stem Cell Transplantation Promotes Neurogenesis and Ameliorates Autism Related Behaviors in BTBR Mice.

Segal-Gavish H, Karvat G, Barak N, Barzilay R, Ganz J, Edry L, Aharony I, Offen D, Kimchi T.

Autism Res. 2016 Jan;9(1):17-32. doi: 10.1002/aur.1530. 



A DJ-1 Based Peptide Attenuates Dopaminergic Degeneration in Mice Models of Parkinson's Disease via Enhancing Nrf2.

Lev N, Barhum Y, Ben-Zur T, Aharony I, Trifonov L, Regev N, Melamed E, Gruzman A, Offen D.

PLoS One. 2015 May 29;10(5):e0127549. doi: 10.1371/journal.pone.0127549. 

DJ-1 knockout augments disease severity and shortens survival in a mouse model of ALS.

Lev N, Barhum Y, Lotan I, Steiner I, Offen D.

PLoS One. 2015 Mar 30;10(3):e0117190. doi: 10.1371/journal.pone.0117190. 

A chemical chaperone-based drug candidate is effective in a mouse model of amyotrophic lateral sclerosis (ALS).

Getter T, Zaks I, Barhum Y, Ben-Zur T, Böselt S, Gregoire S, Viskind O, Shani T, Gottlieb H, Green O, Shubely M, Senderowitz H, Israelson A, Kwon I, Petri S, Offen D, Gruzman A.

ChemMedChem. 2015 May;10(5):850-61. doi: 10.1002/cmdc.201500045. 

A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits.

Aharony I, Ehrnhoefer DE, Shruster A, Qiu X, Franciosi S, Hayden MR, Offen D.

Hum Mol Genet. 2015 May 1;24(9):2604-14. doi: 10.1093/hmg/ddv023. 

Transplanted modified muscle progenitor cells expressing a mixture of neurotrophic factors delay disease onset and enhance survival in the SOD1 mouse model of ALS.

Dadon-Nachum M, Ben-Yaacov K, Ben-Zur T, Barhum Y, Yaffe D, Perlson E, Offen D.

J Mol Neurosci. 2015 Mar;55(3):788-97. doi: 10.1007/s12031-014-0426-0. 




Safety of repeated transplantations of neurotrophic factors-secreting human mesenchymal stromal stem cells.

Gothelf Y, Abramov N, Harel A, Offen D.

Clin Transl Med. 2014 Jul 10;3:21. doi: 10.1186/2001-1326-3-21.

Dopaminergic-like neurons derived from oral mucosa stem cells by developmental cues improve symptoms in the hemi-parkinsonian rat model.

Ganz J, Arie I, Buch S, Zur TB, Barhum Y, Pour S, Araidy S, Pitaru S, Offen D.

PLoS One. 2014 Jun 19;9(6):e100445. doi: 10.1371/journal.pone.0100445.

Alginate-coated magnetic nanoparticles for noninvasive MRI of extracellular calcium.

Bar-Shir A, Avram L, Yariv-Shoushan S, Anaby D, Cohen S, Segev-Amzaleg N, Frenkel D, Sadan O, Offen D, Cohen Y.

NMR Biomed. 2014 Jul;27(7):774-83. doi: 10.1002/nbm.3117.

Harnessing neurogenesis for the possible treatment of Parkinson's disease.

Lamm O, Ganz J, Melamed E, Offen D.

J Comp Neurol. 2014 Aug 15;522(12):2817-30. doi: 10.1002/cne.23607. Epub 2014 May 9. Review.

Astrocyte-like cells derived from human oral mucosa stem cells provide neuroprotection in vitro and in vivo.

Ganz J, Arie I, Ben-Zur T, Dadon-Nachum M, Pour S, Araidy S, Pitaru S, Offen D.

Stem Cells Transl Med. 2014 Mar;3(3):375-86. doi: 10.5966/sctm.2013-0074. 

Targeting neurogenesis ameliorates danger assessment in a mouse model of Alzheimer's disease.

Shruster A, Offen D.

Behav Brain Res. 2014 Mar 15;261:193-201. doi: 10.1016/j.bbr.2013.12.028. Epub 2013 Dec 31.

Rare combination of myasthenia and motor neuronopathy, responsive to Msc-Ntf stem cell therapy.

Petrou P, Argov A, Lennon VA, Gotkine M, Kassis I, Vaknin-Dembinsky A, Ben-Hur T, Offen D, Abramsky O, Melamed E, Karussis D.

Muscle Nerve. 2014 Mar;49(3):455-7. doi: 10.1002/mus.24143.

Dominant negative DISC1 mutant mice display specific social behaviour deficits and aberration in BDNF and cannabinoid receptor expression.

Kaminitz A, Barzilay R, Segal H, Taler M, Offen D, Gil-Ad I, Mechoulam R, Weizman A.

World J Biol Psychiatry. 2014 Jan;15(1):76-82. doi: 10.3109/15622975.2013.841993.


Immunohistochemical analysis of sympathetic involvement in the SOD1-G93A transgenic mouse model of amyotrophic lateral sclerosis.

Kandinov B, Grigoriadis NC, Touloumi O, Drory VE, Offen D, Korczyn AD.

Amyotroph Lateral Scler Frontotemporal Degener. 2013 Sep;14(5-6):424-33. doi: 10.3109/21678421.2013.780622.

Knocking out DJ-1 attenuates astrocytes neuroprotection against 6-hydroxydopamine toxicity.

Lev N, Barhum Y, Ben-Zur T, Melamed E, Steiner I, Offen D.

J Mol Neurosci. 2013 Jul;50(3):542-50. doi: 10.1007/s12031-013-9984-9. Epub 2013 Mar 28.

Cell and gene therapy in Alzheimer's disease.

Glat MJ, Offen D.

Stem Cells Dev. 2013 May 15;22(10):1490-6. doi: 10.1089/scd.2012.0633. Epub 2013 Mar 4. Review.

Altered astrocytic response to activation in SOD1(G93A) mice and its implications on amyotrophic lateral sclerosis pathogenesis.

Benkler C, Ben-Zur T, Barhum Y, Offen D.

Glia. 2013 Mar;61(3):312-26. doi: 10.1002/glia.22428.

Mesenchymal stem cells protect from sub-chronic phencyclidine insult in vivo and counteract changes in astrocyte gene expression in vitro.

Barzilay R, Ganz J, Sadan O, Ben-Zur T, Bren Z, Hinden N, Taler M, Lev N, Gil-Ad I, Weizman A, Offen D.

Eur Neuropsychopharmacol. 2013 Sep;23(9):1115-23. doi: 10.1016/j.euroneuro.2012.10.002. 


Intrastriatal transplantation of neurotrophic factor-secreting human mesenchymal stem cells improves motor function and extends survival in R6/2 transgenic mouse model for Huntington's disease.

Sadan O, Melamed E, Offen D.

PLoS Curr. 2012 Jul 10;4:e4f7f6dc013d4e. doi: 10.1371/4f7f6dc013d4e.

DJ-1 protects against dopamine toxicity: implications for Parkinson's disease and aging.

Lev N, Barhum Y, Pilosof NS, Ickowicz D, Cohen HY, Melamed E, Offen D.

J Gerontol A Biol Sci Med Sci. 2013 Mar;68(3):215-25. doi: 10.1093/gerona/gls147.

Wnt signaling enhances neurogenesis and improves neurological function after focal ischemic injury.

Shruster A, Ben-Zur T, Melamed E, Offen D.

PLoS One. 2012;7(7):e40843. doi: 10.1371/journal.pone.0040843. 

Transplantation of placenta-derived mesenchymal stem cells in the EAE mouse model of MS.

Fisher-Shoval Y, Barhum Y, Sadan O, Yust-Katz S, Ben-Zur T, Lev N, Benkler C, Hod M, Melamed E, Offen D.

J Mol Neurosci. 2012 Sep;48(1):176-84. doi: 10.1007/s12031-012-9805-6.

Mesenchymal stem cells induced to secrete neurotrophic factors attenuate quinolinic acid toxicity: a potential therapy for Huntington's disease.

Sadan O, Shemesh N, Barzilay R, Dadon-Nahum M, Blumenfeld-Katzir T, Assaf Y, Yeshurun M, Djaldetti R, Cohen Y, Melamed E, Offen D.

Exp Neurol. 2012 Apr;234(2):417-27. doi: 10.1016/j.expneurol.2011.12.045.

Therapeutic effect of myogenic cells modified to express neurotrophic factors in a rat model of sciatic nerve injury.

Dadon-Nachum M, Ben-Zur T, Srugo I, Shamir HM, Melamed E, Yaffe D, Offen D.

J Stem Cells Regen Med. 2012 Apr 14;8(1):21-7. 

Mapping apparent eccentricity and residual ensemble anisotropy in the gray matter using angular double-pulsed-field-gradient MRI.

Shemesh N, Barazany D, Sadan O, Bar L, Zur Y, Barhum Y, Sochen N, Offen D, Assaf Y, Cohen Y.

Magn Reson Med. 2012 Sep;68(3):794-806. doi: 10.1002/mrm.23300. 

Placental mesenchymal stromal cells induced into neurotrophic factor-producing cells protect neuronal cells from hypoxia and oxidative stress.

Yust-Katz S, Fisher-Shoval Y, Barhum Y, Ben-Zur T, Barzilay R, Lev N, Hod M, Melamed E, Offen D.

Cytotherapy. 2012 Jan;14(1):45-55. doi: 10.3109/14653249.2011.613928. 




Stem cells treatment for sciatic nerve injury.

Dadon-Nachum M, Melamed E, Offen D.

Expert Opin Biol Ther. 2011 Dec;11(12):1591-7. doi: 10.1517/14712598.2011.628933. Review.


Cell replacement therapy for Parkinson's disease: how close are we to the clinic?

Ganz J, Lev N, Melamed E, Offen D.

Expert Rev Neurother. 2011 Sep;11(9):1325-39. doi: 10.1586/ern.11.74. Review.



Striatal microinjection of Sydenham chorea antibodies: using a rat model to examine the dopamine hypothesis.

Ben-Pazi H, Sadan O, Offen D.

J Mol Neurosci. 2012 Jan;46(1):162-6. doi: 10.1007/s12031-011-9559-6.

Differentiated mesenchymal stem cells for sciatic nerve injury.

Dadon-Nachum M, Sadan O, Srugo I, Melamed E, Offen D.

Stem Cell Rev. 2011 Sep;7(3):664-71. doi: 10.1007/s12015-010-9227-1.

Intracerebral adult stem cells transplantation increases brain-derived neurotrophic factor levels and protects against phencyclidine-induced social deficit in mice.

Barzilay R, Ben-Zur T, Sadan O, Bren Z, Taler M, Lev N, Tarasenko I, Uzan R, Gil-Ad I, Melamed E, Weizman A, Offen D.

Transl Psychiatry. 2011 Dec 13;1:e61. doi: 10.1038/tp.2011.64.

Wnt signaling pathway overcomes the disruption of neuronal differentiation of neural progenitor cells induced by oligomeric amyloid β-peptide.

Shruster A, Eldar-Finkelman H, Melamed E, Offen D.

J Neurochem. 2011 Feb;116(4):522-9. doi: 10.1111/j.1471-4159.2010.07131.


The "dying-back" phenomenon of motor neurons in ALS.

Dadon-Nachum M, Melamed E, Offen D.

J Mol Neurosci. 2011 Mar;43(3):470-7. doi: 10.1007/s12031-010-9467-1. Review.

Intravitreal injections of neurotrophic factors secreting mesenchymal stem cells are neuroprotective in rat eyes following optic nerve transection.

Levkovitch-Verbin H, Sadan O, Vander S, Rosner M, Barhum Y, Melamed E, Offen D, Melamed S.

Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6394-400. doi: 10.1167/iovs.09-4310.

Mesenchymal stem cells stimulate endogenous neurogenesis in the subventricular zone of adult mice.

Kan I, Barhum Y, Melamed E, Offen D.

Stem Cell Rev. 2011 Jun;7(2):404-12. doi: 10.1007/s12015-010-9190-x.

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